LIFR Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 25-100 Positive control: Human colon cancer Predicted cell location: Cytoplasm, Nucleus
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 115-128 amino acids of Human leukemia inhibitory factor receptor alpha
Isotype	IgG
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	leukemia inhibitory factor receptor alpha
Database Link	NP_002301 Entrez Gene 3977 Human UniProt ID P42702
Background	This gene encodes a protein that belongs to the type I cytokine receptor family. This protein combines with a high-affinity converter subunit; gp130; to form a receptor complex that mediates the action of the leukemia inhibitory factor; a polyfunctional cytokine that is involved in cellular differentiation; proliferation and survival in the adult and the embryo. Mutations in this gene cause Schwartz-Jampel syndrome type 2; a disease belonging to the group of the bent-bone dysplasias. A translocation that involves the promoter of this gene; t(5;8)(p13;q12) with the pleiomorphic adenoma gene 1; is associated with salivary gland pleiomorphic adenoma; a common type of benign epithelial tumor of the salivary gland. Multiple splice variants encoding the same protein have been found for this gene.
Synonyms	CD118; LIF-R; SJS2; STWS; SWS
Reference Data
Protein Families	Druggable Genome, Secreted Protein, Transmembrane
Protein Pathways	Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway

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