Sumo 1 (SUMO1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 15-50 Positive control: Human lung cancer Predicted cell location: Cytoplasm, Nucleus
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 56-70 amino acids of Human SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)
Isotype	IgG
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	small ubiquitin-like modifier 1
Database Link	NP_003343 Entrez Gene 22218 MouseEntrez Gene 301442 RatEntrez Gene 7341 Human UniProt ID P63165
Background	This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However; unlike ubiquitin which targets proteins for degradation; this protein is involved in a variety of cellular processes; such as nuclear transport; transcriptional regulation; apoptosis; and protein stability. It is not active until the last four amino acids of the carboxy-terminus have been cleaved off. Several pseudogenes have been reported for this gene. Alternate transcriptional splice variants encoding different isoforms have been characterized.
Synonyms	DAP1; GMP1; OFC10; PIC1; SENP2; SMT3; SMT3C; SMT3H3; UBL1
Reference Data
Protein Families	Druggable Genome, Stem cell - Pluripotency, Transcription Factors

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