ABCG2 Rabbit Polyclonal Antibody
CAT#: TA322704S
Anti-ABCG2 Rabbit Polyclonal Antibody
Size: 100 ul
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Specifications
| Product Data | |
| Applications | IHC, WB |
| Recommend Dilution | WB: 200-1000 WB positive control: LO2 and 293T cell lysates IHC: 50-100 Positive control: Human esophagus cancer Predicted cell location: Cytoplasm and Cell membrane |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide corresponding to a region derived from 609-621 amino acids of Human ATP-binding cassette sub-family G member 2 |
| Isotype | IgG |
| Formulation | PBS pH7.3, 0.05% NaN3, 50% glycerol |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage Condition | Store at -20°C as received. |
| Predicted Protein Size | 72 kDa |
| Gene Name | ATP binding cassette subfamily G member 2 (Junior blood group) |
| Database Link | |
| Background | The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1; MDR/TAP; MRP; ALD; OABP; GCN20; White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein; this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta; which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene. |
| Synonyms | ABC15; ABCP; BCRP; BCRP1; BMDP; CD338; CDw338; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1; UAQTL1 |
| Reference Data | |
| Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Transmembrane |
| Protein Pathways | ABC transporters |
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