Laminin alpha 5 (LAMA5) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 10-50 Positive control: Human thyroid cancer Predicted cell location: Cytoplasm, Cell membrane
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 64-77 amino acids of Human laminin, alpha 5
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	laminin subunit alpha 5
Database Link	NP_005551 Entrez Gene 3911 Human UniProt ID O15230
Background	Components of the extracellular matrix exert myriad effects on tissues throughout the body. In particular; the laminins; a family of heterotrimeric extracellular glycoproteins; affect tissue development and integrity in such diverse organs as the kidney; lung; skin; and nervous system. It is thought that laminins mediate the attachment; migration; and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminins function as heterotrimeric complexes of alpha; beta; and gamma chains; with each chain type representing a different subfamily of proteins. The protein encoded by this gene belongs to the alpha subfamily of laminin chains and is a major component of basement membranes. Two transcript variants encoding different isoforms have been found for this gene; but the full-length nature of one of them has not been determined.
Synonyms	KIAA1907
Reference Data
Protein Families	Druggable Genome
Protein Pathways	ECM-receptor interaction, Focal adhesion, Pathways in cancer, Small cell lung cancer

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