RAMP3 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 50-200 Positive control: Human ovarian cancer Predicted cell location: Cytoplasm
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein corresponding to a region derived from 24-118 amino acids of human receptor (G protein-coupled) activity modifying protein 3
Isotype	IgG
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	receptor (G protein-coupled) activity modifying protein 3
Database Link	NP_005847 Entrez Gene 56089 MouseEntrez Gene 56820 RatEntrez Gene 10268 Human UniProt ID O60896
Background	The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins; called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR; a receptor with seven transmembrane domains; can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor; depending on which members of the RAMP family are expressed. In the presence of this (RAMP3) protein; CRLR functions as an adrenomedullin receptor.
Synonyms	calcitonin receptor-like receptor activity modifying protein 3; receptor (calcitonin) activity modifying protein 3; receptor (G protein-coupled) activity modifying protein 3; receptor-activity-modifying protein 3; receptor activity modifying protein 3
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Vascular smooth muscle contraction

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