MDC1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 100-300 Positive control: Human brain Predicted cell location: Cytoplasm, Nucleus
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 1866-1881 amino acids of Human mediator of DNA-damage checkpoint 1
Isotype	IgG
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	mediator of DNA damage checkpoint 1
Database Link	NP_055456 Entrez Gene 9656 Human UniProt ID Q14676
Background	The protein encoded by this gene contains an N-terminal forkhead domain; two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs; and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci.
Synonyms	NFBD1
Reference Data

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