Spindly (SPDL1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 500-2000 WB positive control: Hela, 293T, Jurkat cell, Mouse testis tissue, K562, A549 cell lysates IHC: 50-200 Positive control: Human thyroid cancer Predicted cell location: Nucleus
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein corresponding to C terminal 250 amino acids of human spindle apparatus coiled-coil protein 1
Isotype	IgG
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	spindle apparatus coiled-coil protein 1
Database Link	NP_060255 Entrez Gene 70385 MouseEntrez Gene 54908 Human UniProt ID Q96EA4
Background	Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. Interacts with KNTC1 and ZW10. These interactions appear weak and may be transient or indirect.
Synonyms	CCDC99
Reference Data

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