ADAMTS5 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 50-100 Positive control: Human liver cancer Predicted cell location: Secreted
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 529-541 amino acids of Human A disintegrin and metalloproteinase with thrombospondin motifs 5
Isotype	IgG
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	ADAM metallopeptidase with thrombospondin type 1 motif 5
Database Link	NP_008969 Entrez Gene 23794 MouseEntrez Gene 11096 Human UniProt ID Q9UNA0
Background	This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules; including a propeptide region; a metalloproteinase domain; a disintegrin-like domain; and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs; and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs and functions as aggrecanase to cleave aggrecan; a major proteoglycan of cartilage.
Synonyms	ADAM-TS 5; ADAM-TS5; ADAM-TS 11; ADAMTS-5; ADAMTS-11; ADAMTS11; ADMP-2
Reference Data
Protein Families	Druggable Genome, Protease, Secreted Protein

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