GDF15 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 150-300 Positive control: Human liver cancer Predicted cell location: Secreted
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein corresponding to a region derived from 195-308 amino acids of human growth differentiation factor 15
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	growth differentiation factor 15
Database Link	NP_004855 Entrez Gene 9518 Human UniProt ID Q99988
Background	Bone morphogenetic proteins (e.g.; BMP9; MIM 605120) are members of the transforming growth factor-beta (see TGFB1; MIM 190180) superfamily and regulate tissue differentiation and maintenance. They are synthesized as precursor molecules that are processed at a dibasic cleavage site to release C-terminal domains containing a characteristic motif of 7 conserved cysteines in the mature protein. GDF15 mRNA is most abundant in the liver; with lower levels seen in some other tissues. Its expression in liver can be significantly up-regulated in during injury of organs such as liver; kidney; heart and lung.
Synonyms	GDF-15; MIC-1; MIC1; NAG-1; PDF; PLAB; PTGFB
Reference Data
Protein Families	Druggable Genome, Secreted Protein

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