VNN1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF
Recommend Dilution	IF: 100-500 Positive control: HepG2 and NCCIT cell Predicted cell location: Cytoplasm
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 483-496 amino acids of human vanin 1
Isotype	IgG
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	vanin 1
Database Link	NP_004657 Entrez Gene 8876 Human UniProt ID O95497
Background	This gene encodes a member of the vanin family of proteins; which share extensive sequence similarity with each other; and also with biotinidase. The family includes secreted and membrane-associated proteins; a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins; however; they possess pantetheinase activity; which may play a role in oxidative-stress response. This protein; like its mouse homolog; is likely a GPI-anchored cell surface molecule. The mouse protein is expressed by the perivascular thymic stromal cells and regulates migration of T-cell progenitors to the thymus. This gene lies in close proximity to; and in the same transcriptional orientation as; two other vanin genes on chromosome 6q23-q24.
Synonyms	HDLCQ8; Tiff66
Reference Data
Protein Pathways	Pantothenate and CoA biosynthesis

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