p27 KIP 1 (CDKN1B) Rabbit Polyclonal Antibody
CAT＃: TA321617S
Anti-CDKN1B Rabbit Polyclonal Antibody
Size: 100 ul
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CNY 800.00
CNY 1280.00
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CNY 300.00
CNY 1430.00
CNY 2900.00
CNY 6650.00
CNY 3080.00
Specifications
| Product Data | |
| Applications | IHC, WB |
| Recommend Dilution | WB: 500-2000 WB positive control: Jurkat and Raji cell lysates IHC: 50-100 Positive control: Human prostate cancer Predicted cell location: Cytoplasm and Nucleus |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Full length fusion protein |
| Isotype | IgG |
| Formulation | PBS pH7.3, 0.05% NaN3, 50% glycerol |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage Condition | Store at -20°C as received. |
| Predicted Protein Size | 22 kDa |
| Gene Name | cyclin-dependent kinase inhibitor 1B |
| Database Link | |
| Background | This gene encodes a cyclin-dependent kinase inhibitor; which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes; and thus controls the cell cycle progression at G1. The degradation of this protein; which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes; is required for the cellular transition from quiescence to the proliferative state. |
| Synonyms | CDKN4; KIP1; MEN1B; MEN4; P27KIP1 |
| Reference Data | |
| Protein Families | Druggable Genome |
| Protein Pathways | Cell cycle, Chronic myeloid leukemia, ErbB signaling pathway, Pathways in cancer, Prostate cancer, Small cell lung cancer |
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