BNP (NPPB) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 50-200 Positive control: Human cervical cancer Predicted cell location: Secreted
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 77-90 amino acids of Human natriuretic peptide B
Isotype	IgG
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	natriuretic peptide B
Database Link	NP_002512 Entrez Gene 4879 Human UniProt ID P16860
Background	This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events; one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis; diuresis; vasorelaxation; inhibition of renin and aldosterone secretion; and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. Mutations in this gene have been associated with postmenopausal osteoporosis.
Synonyms	BNP
Reference Data
Protein Families	Druggable Genome, Secreted Protein, Stem cell - Pluripotency

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