Leptin Receptor (LEPR) Rabbit Polyclonal Antibody

CAT#: TA321465S

Anti-LEPR Rabbit Polyclonal Antibody

Size: 25 ul 100 ul



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CNY 800.00

CNY 1,280.00


货期*
2周

规格
    • 25 ul

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Transient overexpression lysate of leptin receptor (LEPR), transcript variant 1
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Specifications

Product Data
Applications IHC
Recommend Dilution IHC: 25-100
Positive control: Human breast cancer
Predicted cell location: Cytoplasm
Reactivity Human
Host Rabbit
Clonality Polyclonal
Immunogen Synthetic peptide corresponding to a region derived from 585-597 amino acids of human leptin receptor
Formulation PBS pH7.3, 0.05% NaN3, 50% glycerol
Purification Antigen affinity purification
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name leptin receptor
Background The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight); and is involved in the regulation of fat metabolism; as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons; however; encode distinct proteins (PMID:9207021).
Synonyms CD295; LEP-R; LEPRD; OB-R; OBR
Reference Data
Protein Families Druggable Genome, Secreted Protein, Transmembrane
Protein Pathways Adipocytokine signaling pathway, Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Neuroactive ligand-receptor interaction
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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