CYP1A1 Rabbit Polyclonal Antibody
CAT＃: TA321142S
Anti-CYP1A1 Rabbit Polyclonal Antibody
Size: 100 ul
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CNY 800.00
CNY 1280.00
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CNY 300.00
CNY 1430.00
CNY 2900.00
CNY 6650.00
CNY 3080.00
Specifications
| Product Data | |
| Applications | IHC, WB |
| Recommend Dilution | WB: 500-2000 WB positive control: Mouse liver tissue IHC: 25-100 Positive control: Human liver cancer Predicted cell location: Cytoplasm |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Fusion protein corresponding to C terminal 300 amino acids of human cytochrome P450, family 1, subfamily A, polypeptide 1 |
| Isotype | IgG |
| Formulation | PBS pH7.3, 0.05% NaN3, 50% glycerol |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage Condition | Store at -20°C as received. |
| Predicted Protein Size | 58 kDa |
| Gene Name | cytochrome P450 family 1 subfamily A member 1 |
| Database Link | |
| Background | This gene; CYP1A1; encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol; steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs); some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however; it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member; CYP1A2; is located approximately 25 kb away from CYP1A1 on chromosome 15. |
| Synonyms | AHH; AHRR; CP11; CYP1; CYPIA1; P1-450; P450-C; P450DX |
| Reference Data | |
| Protein Families | Druggable Genome, P450, Transmembrane |
| Protein Pathways | Metabolism of xenobiotics by cytochrome P450, Retinol metabolism, Tryptophan metabolism |
Documents
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