Factor IX (F9) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 25-100 Positive control: Human colon cancer Predicted cell location: Cytoplasm
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein corresponding to a region derived from 227-461 amino acids of human coagulation factor IX
Isotype	IgG
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	coagulation factor IX
Database Link	NP_000124 Entrez Gene 14071 MouseEntrez Gene 24946 RatEntrez Gene 2158 Human UniProt ID P00740
Background	This gene encodes vitamin K-dependent coagulation factor IX that circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa; which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca+2 ions; membrane phospholipids; and factor VIII. Alterations of this gene; including point mutations; insertions and deletions; cause factor IX deficiency; which is a recessive X-linked disorder; also called hemophilia B or Christmas disease.
Synonyms	FIX; HEMB; P19; PTC; THPH8
Reference Data
Protein Families	Druggable Genome, Protease, Secreted Protein
Protein Pathways	Complement and coagulation cascades

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