Cd9 Rat Monoclonal Antibody [Clone ID: eBioKMC8 (KMC8)]

Specifications

Product Data
Clone Name	eBioKMC8 (KMC8)
Applications	FC
Recommend Dilution	Flow, WB
Reactivity	Mouse
Host	Rat
Clonality	Monoclonal
Formulation	Aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration	lot specific
Purification	Affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	CD9 antigen
Database Link	NP_031683 Entrez Gene 12527 Mouse UniProt ID P40240
Background	The eBioKMC8 monoclonal antibody reacts with mouse CD9, a 24 kDa member of the transmembrane 4 superfamily. This family is characterized by the presence of four hydrophobic domains spanning the cell membrane and short N- and C-terminal cytoplasmic domains. CD9 is expressed by several cell types including monocytes, macrophages, platelets, early B cells, activated B and T cells, dendritic cells, eosinophils, basophils, endothelial cells, myoblasts and neuroblasts. On T cells, CD9 functions as a co-stimulatory molecule on na?ve T cells. Furthermore, CD9 is expressed in oocytes, and CD9-deficiency results in sterility caused by defective gamete fusion. In mouse macrophages, CD9 functionally associates with FcγRs to modify signals for phagocytosis and inflammatory responses. In mouse B cells, it was discovered that CD9 is a marker for marginal zone B cells, B1 cells, and plasma cells. In dendritic cells, recently it was demonstrated that CD9 facilitates the association of heterologous MHC II molecules. The level of CD9 expression is subject to donor variability.
Synonyms	5H9; BA2; BTCC-1; DRAP-27; GIG2; MIC3; MRP-1; OTTHUMP00000041576; P24; Tetraspanin-29; Tspan-29; TSPAN29
Reference Data

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