LEMD2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB: 1 - 2 ug/mL
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	LEMD2 antibody was raised against a 16 amino acid synthetic peptide near the center of human LEMD2.
Isotype	IgG
Formulation	LEMD2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	LEMD2 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	LEM domain containing 2
Database Link	NP_851853 Entrez Gene 224640 MouseEntrez Gene 221496 Human UniProt ID Q8NC56
Background	LEMD2 Antibody: The LEM (lamina-associated polypeptide-emerin-MAN1) domain is a motif shared by a group of lamin-interacting proteins of the inner nuclear membrane (INM) and nucleoplasm. One such protein, LEMD2 (LEM domain-containing protein 2), is a lamina-associated protein in the INM involved in nuclear structure organization, containing an N-terminal LEM motif, two transmembrane domains, and a MAN1-Src1p C-terminal (MSC) domain. LEMD2 is a truncated paralog of MAN1, lacking the MAN1-specific C-terminal RNA-recognition motif, but like MAN1 is required for myogenic differentiation. Mutations in LEMD2 are thought be among the possible causes of muscle disease.
Synonyms	CTRCT42; dJ482C21.1; NET25
Reference Data
Protein Families	Transmembrane

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