Prickle (PRICKLE1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB: 1 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	PRICKLE1 antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human PRICKLE1.
Isotype	IgG
Formulation	PRICKLE1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	PRICKLE1 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	prickle planar cell polarity protein 1
Database Link	NP_694571 Entrez Gene 106042 MouseEntrez Gene 315259 RatEntrez Gene 144165 Human UniProt ID Q96MT3
Background	PRICKLE1 Antibody: PRICKLE1, also known as RILP or EPM1B, is a Disheveled-associated protein that serves as a nuclear translocation receptor for REST/NRSF and REST4 (1, 2). It contains three N-terminal LIM domains and three C-terminal nuclear localization signals. It localizes to the cytoplasm, as well as to the nuclear membrane and expressed at higher levels in placenta. PRICKLE1 is a negative regulator of the Wnt / beta-catenin signaling pathway and is a putative tumor suppressor in human HCCs. Defects in the gene encoding PRICKLE1 are associated with autosomal recessive progressive myoclonic epilepsy.
Synonyms	EPM1B; RILP
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Wnt signaling pathway

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