NALP5 (NLRP5) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 ug/mL, ICC: 10 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	NALP5 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of human NALP5.
Isotype	IgG
Formulation	NALP5 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	NALP5 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	NLR family, pyrin domain containing 5
Database Link	NP_703148 Entrez Gene 23968 MouseEntrez Gene 308325 RatEntrez Gene 126206 Human UniProt ID P59047
Background	NALP5 Antibody: NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction. NALP5, also known as MATER, is a maternal gene required for early embryonic development in mice. Increased NALP5 expression was observed in two neuronal injury models, and transient expression of recombinant NALP5 in neurons induced caspase-3 activation and apoptosis, suggesting that NALP5 also plays a role in caspase activation and apoptosis in injured neurons, and may thus represent a novel target for therapeutic treatment in neurodegenerative disorders.
Synonyms	CLR19.8; MATER; NALP5; PAN11; PYPAF8
Reference Data

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