NDFIP1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 0.5 - 1 ug/mL
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	NDFIP1 antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of human NDFIP1.
Isotype	IgG
Formulation	NDFIP1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	NDFIP1 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	24 kDa
Gene Name	Nedd4 family interacting protein 1
Database Link	NP_085048 Entrez Gene 65113 MouseEntrez Gene 80762 Human UniProt ID Q9BT67
Background	NDFIP1 Antibody: The NEDD4 family-interacting protein 1 (NDFIP1) belongs to a small group of evolutionarily conserved proteins with three transmembrane domains and is an integral Golgi membrane protein. It is a potential target for ubiquitination by the Nedd4 family of proteins. NDFIP1 is strongly expressed in surviving neurons following acute cortical brain injury, and overexpression in cultured cortical neurons increased survival following growth factor starvation, suggesting that NDFIP1 may play a role in neuronal survival. NDFIP1 and the related protein NDFIP2 are thought to interact with and regulate multiple components of the EGF and PTEN/Akt signaling pathways. Recent studies suggest that NDFIP1 may also play a role in Th17 differentiation by limiting the production of proinflammatory cytokines.
Synonyms	N4WBP5
Reference Data
Protein Families	Transmembrane

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