FLJ14213 (PRR5L) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB: 1 ug/mL, ICC: 10 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	PRR5L antibody was raised against a 17 amino acid synthetic peptide near the center of human PRR5L.
Isotype	IgG
Formulation	PRR5L Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	PRR5L Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	proline rich 5 like
Database Link	NP_001153639 Entrez Gene 79899 Human UniProt ID Q6MZQ0
Background	PRR5L Antibody: Proline-rich protein 5-like (PRR5L), also known as Protor-2, is structurally similar to PRR5 and also binds to the mTOR complex 2 (mTORC2). PRR5L is not required for mTORC2 integrity or kinase activity, but dissociates from mTORC2 upon knockdown of tuberous sclerosis complex 1 (TSC1) and TSC2. Knockdown of PRR5L reduced apoptosis in mTORC2 deficient cells as well as cells where mTOR was active, suggesting that mTORC2-dissociated PRR5L may promote apoptosis, and thus play a role in the balance between cell growth and cell death.
Synonyms	PROTOR2
Reference Data

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