TCTN2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1 ug/mL
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	TCTN2 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human TCTN2.
Isotype	IgG
Formulation	TCTN2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	TCTN2 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	tectonic family member 2
Database Link	NP_079085 Entrez Gene 79867 Human UniProt ID Q96GX1
Background	TCTN2 Antibody: TCTN2 is a member of the Tectonic protein family, a group of evolutionarily conserved secreted and transmembrane proteins that regulate the Hedgehog (Hh)-mediated patterning of the neural tube. While the expression pattern and function of TCTN2 is not known, it is 49% similar to TCTN1. TCTN1 is expressed during embryonic development in regions that participate in Hh signaling, beginning in the gastrulation stages in the ventral node. Mice expressing mutant TCTN1 die between E13.5 and E16.5 and display holoprosencephaly, a defect associated with reduced Hh signaling, indicating the role of TCTN1 as an Hh activator. At later stages in development, TCTN1 is thought to also act as a repressor on the Hh pathway in the anterior and posterior neural tube.
Synonyms	C12orf38; JBTS24; MKS8; TECT2
Reference Data

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