Apg3 (ATG3) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 - 2 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	ATG3 antibody was raised against an 18 amino acid synthetic peptide near the center of human ATG3.
Isotype	IgG
Formulation	ATG3 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	ATG3 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	autophagy related 3
Database Link	NP_071933 Entrez Gene 67841 MouseEntrez Gene 171415 RatEntrez Gene 64422 Human UniProt ID Q9NT62
Background	ATG3 Antibody: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1. ATG3 (APG3) is a widely expressed conjugating enzyme for APG8 lipidation, an essential step for the initiation of autophagy. It functions as an E2-like enzyme during the initial stages of autophagosome formation by catalyzing the formation of the Atg8-phosphatidylethanolamine (Atg8-PE) conjugate, which is critical for autophagy.
Synonyms	APG3; APG3-LIKE; APG3L; PC3-96
Reference Data
Protein Pathways	Regulation of autophagy

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