ATG2B Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB: 1 - 2 ug/mL, IF: 20 ug/mL
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	ATG2B antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of human ATG2B.
Isotype	IgG
Formulation	ATG2B Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	ATG2B Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	229 kDa
Gene Name	autophagy related 2B
Database Link	NP_060506 Entrez Gene 55102 Human UniProt ID Q96BY7
Background	ATG2B Antibody: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1. Another member of the autophagy family of proteins is ATG2B, one of two homologs of ATG2 that is essential for autophagosome formation and important for regulation of size and distribution of lipid droplets. Relatively high rates of ATG2B mutations were observed in gastric and colorectal carcinomas, suggesting that deregulating the autophagy process may contribute to cancer development.
Synonyms	C14orf103
Reference Data

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