DDX41 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 - 2 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	DDX41 antibody was raised against a 17 amino acid peptide near the amino terminus of human DDX41.
Isotype	IgG
Formulation	DDX41 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	DDX41 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 68 kDa; Observed: 70 kDa
Gene Name	DEAD-box helicase 41
Database Link	NP_057306 Entrez Gene 72935 MouseEntrez Gene 314336 RatEntrez Gene 51428 Human UniProt ID Q9UJV9
Background	DDX41 Antibody: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp, are putative RNA helicases implicated in several cellular processes involving modifications of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. DDX41, also known as Abstrakt, interacts with and regulates the expression of sorting nexin-2 (SNX2), a protein involved in protein sorting in the trans-Golgi network. Recent evidence suggests that DDX41 also plays a role in the innate immune response by sensing intracellular viral DNA, triggering TBK1 and IRF3 activation, leading to a type I interferon immune response.
Synonyms	ABS
Reference Data
Protein Families	Druggable Genome

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