RGS22 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB: 1 - 2 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	RGS22 antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of human RGS22.
Isotype	IgG
Formulation	RGS22 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	RGS22 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	139 kDa
Gene Name	regulator of G-protein signaling 22
Database Link	NP_056483 Entrez Gene 626596 MouseEntrez Gene 500853 RatEntrez Gene 26166 Human UniProt ID Q8NE09
Background	RGS22 Antibody: Regulator of G-protein signaling (RGS) proteins contain an 120 amino acid conserved domain, termed the RGS domain, that acts as a GTPase-activating protein that acts to reduce the signal transmitted by the receptor-activated G-alpha subunit. RGS22 is a recently identified member of this family that localizes to the testis and can interact with guanine nucleotide binding proteins alpha 11, 12, and 13 (GNA11, GNA12, and GNA13). While RGS22 has been postulated to play a role in spermiogenesis in the testis, it is also expressed in several cancer cell lines with an epithelial origin and associated with cancer metastasis. Its overexpression in a highly metastatic cancer causes a decrease in cell migration and a reduction of the invasive potential of the cells, suggesting that RGS22 may be a potential prognostic biomarker for metastasis.
Synonyms	CT145; PRTD-NY2
Reference Data

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