TAB2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 5 ug/mL
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	TAB2 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of human TAB2.
Isotype	IgG
Formulation	TAB2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	TAB2 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	TGF-beta activated kinase 1/MAP3K7 binding protein 2
Database Link	NP_055908 Entrez Gene 23118 Human UniProt ID Q9NYJ8
Background	TAB2 Antibody: TAB2 is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation NF-kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKL through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Recent experiments have shown that TAB2 and the related protein TAB3 constitutitvely interact with the autophagy mediator Beclin-1; upon induction of autophagy, these proteins dissociate from Beclin-1 and bind TAK1. Overexpression of TAB2 and TAB3 inhibit autophagy, while their depletion triggers it, suggesting that TAB2 and TAB3 act as a control point for autophagy.
Synonyms	CHTD2; MAP3K7IP2; TAB-2
Reference Data
Protein Families	Druggable Genome
Protein Pathways	MAPK signaling pathway, NOD-like receptor signaling pathway, Toll-like receptor signaling pathway

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