PHLPP2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB: 1 ug/mL
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	PHLPP2 antibody was raised against a 20 amino acid synthetic peptide near the carboxy terminus of human PHLPP2.
Isotype	IgG
Formulation	PHLPP2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	PHLPP2 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	156 kDa
Gene Name	PH domain and leucine rich repeat protein phosphatase 2
Database Link	NP_055835 Entrez Gene 23035 Human UniProt ID Q6ZVD8
Background	PHLPP2 Antibody: PHLPP2 is a member of the serine/threonine phosphatase family, which are important regulators of Akt serine-threonine kinases (AKT1, AKT2, AKT3) and conventional/novel protein kinase C (PKC) isoforms. PHLPP1 and PHLPP2 have a similar domain structure and have been shown to dephosphorylate and inactivate, distinct Akt isoforms, at one of the two critical phosphorylation sites required for activation: Serine473. PHLPP2 dephosphorylates AKT1 and AKT3, whereas PHLPP1 is specific for AKT2 and AKT3. PHLPP1 promotes apoptosis and may act as a tumor suppressor. PHLPP2 associates with and is inhibited by adenylyl cyclase type 6 (AC6), thereby allowing Akt activation.
Synonyms	PHLPPL; PPM3B
Reference Data

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