KAP1 (TRIM28) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, WB
Recommend Dilution	TRIM28 antibody can be used for detection of TRIM28 by Western blot at 1 - 2 µg/mL. Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Rabbit polyclonal TRIM28 antibody was raised against a 14 amino acid peptide near the carboxy terminus of human TRIM28.
Specificity	At least three isoforms of TRIM28 are known to exist; this antibody will detect all three isoforms
Isotype	IgG
Formulation	TRIM28 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	TRIM28 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	92 kDa
Gene Name	tripartite motif containing 28
Database Link	NP_005753 Entrez Gene 21849 MouseEntrez Gene 116698 RatEntrez Gene 10155 Human UniProt ID Q13263
Background	TRIM28 Antibody: TRIM28, also known as KAP-1, is a member of the Transcriptional Intermediary Factor 1 (TIF1) subfamily and contains a RING finger, B box, Coiled coil, PHD/TTC, and bromodomain. TRIM28 is a corepressor for Kruppel-associated box (KRAB)-domain-containing zinc finger proteins and plays a critical role in early embryogenesis. TRIM28 acts as a transcriptional mediator by binding liganded nuclear receptors, including retinoic acid (RAR), retinoid X (RXR) and estrogen (ER) receptors. TRIM28 associates with both heterochromatin and euchromatin, causing gene silencing by both HP1 binding and histone deacetylation.
Synonyms	KAP1; PPP1R157; RNF96; TF1B; TIF1B
Reference Data
Protein Families	Protein Kinase, Stem cell - Pluripotency, Transcription Factors

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