EI24 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 1 - 2 ug/mL, ICC: 5 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	EI24 antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human EI24.
Isotype	IgG
Formulation	EI24 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	EI24 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	EI24, autophagy associated transmembrane protein
Database Link	NP_004870 Entrez Gene 13663 MouseEntrez Gene 300514 RatEntrez Gene 9538 Human UniProt ID O14681
Background	EI24 Antibody: The etoposide-induced 24 (EI24) protein is an immediate-early induction target of p53-mediated apoptosis and functions as a tumor suppressor. EI24 contains six transmembrane domains and is localized to the endoplasmic reticulum (ER). It binds to Bcl-2 and may contribute to apoptosis by modulating the activity and function of Bcl-2. EI24 is highly mutated in aggressive breast cancers and its loss in breast cancer tissue correlates with tumor invasiveness. Similar findings in invasive cervical carcinoma suggest that EI24 may be a promising therapeutic target in the treatment of invasive cancer.
Synonyms	EPG4; PIG8; TP53I8
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	p53 signaling pathway

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