Klotho (KL) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 - 2 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	KLOTHO antibody was raised against a 16 amino acid synthetic peptide near the center of human KLOTHO.
Formulation	KLOTHO Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	KLOTHO Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	klotho
Database Link	NP_004786 Entrez Gene 16591 MouseEntrez Gene 83504 RatEntrez Gene 9365 Human UniProt ID Q9UEF7
Background	KLOTHO Antibody: KLOTHO is the systemic anti-aging hormone within the glycosidase1 superfamily. It encodes a type I membrane protein that is abundant in the kidney and brain. In mice, a deficiency in KLOTHO expression leads to various systemic phenotypes resembling human aging such as arteriosclerosis, osteoporosis, and skin atrophy together with growth retardation, short life-span and infertility. Transgenic mice overexpressing KLOTHO have an extended life span by inhibiting insulin/IGF1 signaling. KLOTHO is involved in the regulation of calcium/phosphorus homeostasis by inhibiting the synthesis of active vitamin D and identified as a potential tumor suppressor.
Synonyms	klotho; OTTHUMP00000018796
Reference Data
Protein Families	Secreted Protein, Transmembrane

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