TIAF1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB: 1 ug/mL
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	TIAF antibody was raised against a 16 amino acid peptide near the amino terminus of human TIAF .
Isotype	IgG
Formulation	TIAF Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	TIAF Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 13 kDa; Observed: 14 kDa
Gene Name	TGFB1-induced anti-apoptotic factor 1
Database Link	NP_004731 Entrez Gene 9220 Human UniProt ID O95411
Background	TIAF Antibody: TIAF-1 (TGFB1-induced anti-apoptotic factor 1), also known as MYO18A, is a TGFB1-induced anti-apoptotic factor that functions to inhibit the cytotoxic effects of TNF-alpha, TRADD and FADD. It localizes to the nucleus and significantly up-regulated in activated helper T lymphocytes (TH2) in chronic kidney and liver allograft rejection. Suppression of TIAF1 expression by siRNA prevents UV irradiation-mediated p53 phosphorylation and nuclear translocation. TIAF1 is essential in the p53- and WOX1-mediated cell death and shows an aggregation-dependent control of tumor progression and metastasis, and regulation of cell death.
Synonyms	MAJN; SPR210
Reference Data
Protein Families	Druggable Genome

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