SEC62 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 0.5 - 1 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	SEC62 antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human SEC62.
Isotype	IgG
Formulation	SEC62 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	SEC62 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	SEC62 homolog, preprotein translocation factor
Database Link	NP_003253 Entrez Gene 69276 MouseEntrez Gene 294912 RatEntrez Gene 7095 Human UniProt ID Q99442
Background	SEC62 Antibody: SEC62 is an integral membrane protein located in the rough endoplasmic reticulum (ER) and is part of the SEC61-SEC62-SEC63 complex that is the central component of the protein translocation apparatus of the ER membrane. It is speculated that SEC61-SEC62-SEC63 may perform post-translational protein translocation into the ER and might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. Silencing of this gene with RNAi dramatically reduced the migration and invasive potential of numerous tumor cell lines, suggesting that it may be an attractive target for therapy of various tumors.
Synonyms	Dtrp1; HTP1; TLOC1; TP-1
Reference Data
Protein Families	Druggable Genome, Transmembrane

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