ROCK1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB: 1 ug/mL, ICC: 10 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	ROCK1 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human ROCK1.
Isotype	IgG
Formulation	ROCK1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	ROCK1 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	Rho associated coiled-coil containing protein kinase 1
Database Link	NP_005397 Entrez Gene 19877 MouseEntrez Gene 81762 RatEntrez Gene 6093 Human UniProt ID Q13464
Background	ROCK1 Antibody: ROCK1 is a member of the AGC serine/threonine protein kinase family that regulates the assembly of the actin cytoskeleton. ROCK1 contains a protein kinase domain, a coiled-coil region and a zinc finger region and appears to be present as a dimer. ROCK1, like its isozyme ROCK2, is a downstream target of the small G-protein Rho and plays a role in smooth muscle contraction, malignant cell transformation, tumor invasion and metastasis, and mediates the cellular morphological changes during apoptosis.
Synonyms	P160ROCK; ROCK-I
Reference Data
Protein Families	Druggable Genome, Protein Kinase
Protein Pathways	Axon guidance, Chemokine signaling pathway, Focal adhesion, Leukocyte transendothelial migration, Pathogenic Escherichia coli infection, Regulation of actin cytoskeleton, TGF-beta signaling pathway, Vascular smooth muscle contraction, Wnt signaling pathway

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