GRB10 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB: 1 - 2 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	GRB10 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human GRB10.
Formulation	GRB10 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	GRB10 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	growth factor receptor bound protein 10
Database Link	NP_005302 Entrez Gene 14783 MouseEntrez Gene 498416 RatEntrez Gene 2887 Human UniProt ID Q13322
Background	GRB10 Antibody: GRB10 belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules and function in diverse cellular processes. GRB10 is a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of GRB10 inhibits tyrosine kinase activity and results in growth suppression. GRB10 can also interact with the L isoform of the proapoptotic protein Bim. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts.
Synonyms	Grb-10; GRB-IR; IRBP; MEG1; RSS
Reference Data
Protein Families	Druggable Genome

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