Eif3e Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	ELISA: 1:90,000, WB: 1:1,000
Reactivity	Mouse, Human, Rat, Dog, Bovine, Monkey
Host	Rabbit
Clonality	Polyclonal
Immunogen	This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a region near the C-terminus of mouse EIF3S6/Int6.
Isotype	IgG
Formulation	0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	eukaryotic translation initiation factor 3, subunit E
Database Link	NP_032414 Entrez Gene 3646 HumanEntrez Gene 299872 RatEntrez Gene 475070 DogEntrez Gene 697622 MonkeyEntrez Gene 103692906 RatEntrez Gene 16341 Mouse UniProt ID P60229
Synonyms	eIF3-p46; EIF3-P48; EIF3S6; INT6
Note	This antibody is suitable for Cancer, Immunology and Nuclear Signaling research. Int6 is a candidate tumor suppressor in multiple neoplasms, and in particular, breast and lung cancers. The Int6 locus was initially identified as a common insertion site (CIS) in a genetic screen for transforming sequences in a breast cancer mouse model system. Insertion of mouse mammary tumor virus (MMTV) into this locus results in the production of an amino-terminal truncated gene product. Expression of the truncated Int6 product corresponds to cellular transformation in both in vivo and in vitro systems. This gene product plays a role in regulating translation initiation and is a component of the eIF3 translation initiation complex. There is evidence that suggests that Int6 may impart a negative role in the general translational machinery while promoting an increase in the expression of a subset of stress-responsive genes. Taken together, it is of great interest to further study the mechanism by which Int6 is involved in regulating cell growth.
Reference Data

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