GGA1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	ELISA: 1:10,000 - 1:50,000, WB: 1:500 - 1:3,000, IP: 1:100
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	This affinity-purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 336-352 of Human GGA-1.
Isotype	IgG
Formulation	0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	golgi-associated, gamma adaptin ear containing, ARF binding protein 1
Database Link	NP_001001560 Entrez Gene 26088 Human UniProt ID Q9UJY5
Synonyms	ADP-ribosylation factor binding protein 1; ARF binding protein 1; gamma-adaptin related protein 1; gamma adaptin ear containing; golgi associated; OTTHUMP00000028975; OTTHUMP00000042200
Note	GGA1 (also known as ADP-ribosylation factor binding protein, Golgi-localized, gamma ear-containing, ARF-binding protein 1, Gamma-adaptin related protein 1) plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. This protein mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif. GGA1 is a monomeric protein that interacts with NECAP1, GGA2 and GGA3 as well as RABEP1, RABGEF1 and type-I membrane proteins SORT1, SORL1, LRP3, M6PR/CD-MPR, IGF2R/CI-MPR and BACE1. GGA1 is a ubiquitously membrane-associated protein that is localized to TGN and endosomes. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Lysosome

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