Artemis (DCLRE1C) Goat Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	ELISA: 1:10,000 - 1:20,000, WB: 1:500 - 1:2,000, IHC: 1:1,000
Reactivity	Human
Host	Goat
Clonality	Polyclonal
Immunogen	This affinity purified antibody was prepared from whole goat serum produced by repeated immunizations with a synthetic peptide corresponding aa 482-495 of Human ARTEMIS (DCLRE1C DNA cross-link repair 1C).
Formulation	0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	DNA cross-link repair 1C
Database Link	NP_001029027 Entrez Gene 64421 Human UniProt ID Q96SD1
Synonyms	A-SCID; DCLREC1C; RS-SCID; SCIDA; SNM1C
Note	Artemis has a role in T and B lymphocyte immunodeficiency and in predisposition to lymphoma through the NHEJ pathway of DNA repair. DNA-PKcs regulates Artemis by both phosphorylation and complex formation to permit enzymatic activities that are critical for the hairpin-opening step of V(D)J recombination and for the 5' and 3' overhang processing in non-homologous DNA end joining.
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Cell cycle, Non-homologous end-joining, Primary immunodeficiency

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