Bestrophin (BEST1) Mouse Monoclonal Antibody [Clone ID: E6-6]

Specifications

Product Data
Clone Name	E6-6
Applications	ICC/IF, IHC, IP, WB
Recommend Dilution	Immunocytochemistry/ Immunofluorescence, Immunohistochemistry-Paraffin, Immunohistochemistry, Proximity Ligation Assay, Immunoprecipitation, Knockout Validated, Western Blot: 1:1000, Immunohistochemistry-Frozen, Dual RNAscope ISH-IHC
Reactivity	Human, Porcine, Primate
Host	Mouse
Clonality	Monoclonal
Immunogen	Synthetic peptide conjugated to KLH [KDHMDPYWALENRDEAHS].
Isotype	IgG1, kappa
Formulation	0.1% Sodium Azide
Purification	Ascites
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	68 kDa
Gene Name	bestrophin 1
Database Link	NP_004174 Entrez Gene 7439 Human UniProt ID O76090
Background	Best macular dystrophy (BMD) or vitelliform macular dystrophy (VMD2), is an autosomal form of macular degeneration, characterized by a depressed light peak in the electrooculogram (EOG). It is inherited and has an early onset. Bestrophin is a 68 kDa basolateral plasma membrane protein encoded by the VMD2 gene. Bestrophin's function is still unknown, but data suggests that it is a chloride channel that plays a role in generating the altered EOG in Best disease patients. In addition, Bestrophin is a useful biochemical and histological marker of RPE (retinal pigment epithelial cells) cells.
Synonyms	ARB; BEST; BMD; RP50; TU15B; VMD2
Reference Data
Protein Families	Druggable Genome, Ion Channels: Other, Transmembrane

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