Dopamine Transporter (SLC6A3) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:100, IHC: 1:1000
Reactivity	Human, Monkey
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to amino acid residues from the extracellular loop 2 region conjugated to KLH
Isotype	IgG
Formulation	100 µl in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	88 kDa
Gene Name	solute carrier family 6 member 3
Database Link	NP_001035 Entrez Gene 574143 MonkeyEntrez Gene 6531 Human UniProt ID Q01959
Background	This gene encodes a dopamine transporter which is a member of the sodium- and chloride-dependent neurotransmitter transporter family. The 3' UTR of this gene contains a 40 bp tandem repeat, referred to as a variable number tandem repeat or VNTR, which can be present in 3 to 11 copies. Variation in the number of repeats is associated with idiopathic epilepsy, attention-deficit hyperactivity disorder, dependence on alcohol and cocaine, susceptibility to Parkinson disease and protection against nicotine dependence.
Synonyms	DAT; DAT1; PKDYS
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Parkinson's disease

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