HPRT (HPRT1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	ICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000
Reactivity	Human, Chicken, Dog, Pig, Rabbit, Rat, Xenopus, Zebrafish, Bovine, X. tropicalis
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant fragment corresponding to a region within amino acids 23 and 218 of HPRT (Uniprot ID#P00492)
Isotype	IgG
Formulation	1XPBS, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative.
Purification	Purified by antigen-affinity chromatography.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	25 kDa
Gene Name	hypoxanthine phosphoribosyltransferase 1
Database Link	NP_000185 Entrez Gene 24465 RatEntrez Gene 442945 DogEntrez Gene 3251 Human UniProt ID P00492
Background	HPRT1 has a central role in the generation of purine nucleotides through the purine salvage pathway. HPRT1 catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate (Keebaugh et al., 2007 [PubMed 16928426]). [supplied by OMIM]
Synonyms	HGPRT; HPRT
Note	Seq homology of immunogen across species: Chicken (94%), Dog (96%), Pig (97%), Rabbit (98%), Rat (96%), Xenopus laevis (92%), Zebrafish (93%), Bovine (94%), Xenopus tropicalis (92%)
Reference Data
Protein Families	Druggable Genome, Stem cell - Pluripotency
Protein Pathways	Drug metabolism - other enzymes, Metabolic pathways, Purine metabolism

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