GLDC Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	ICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000
Reactivity	Human, Mouse, Chicken, Rat, Xenopus, Bovine
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant fragment corresponding to a region within amino acids 442 and 723 of Glycine dehydrogenase (Uniprot ID#P23378)
Isotype	IgG
Formulation	1XPBS, 1% BSA, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative.
Purification	Purified by antigen-affinity chromatography.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	113 kDa
Gene Name	glycine decarboxylase
Database Link	NP_000161 Entrez Gene 104174 MouseEntrez Gene 309312 RatEntrez Gene 2731 Human UniProt ID P23378
Background	The enzyme system for cleavage of glycine (glycine cleavage system; GCS; EC 2.1.2.10), which is confined to the mitochondria, is composed of 4 protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). Glycine encephalopathy (GCE; MIM 605899) may be due to a defect in any one of these enzymes; see MIM 238310, MIM 238330, and MIM 238331. [supplied by OMIM]
Synonyms	GCE; GCSP; HYGN1
Note	Seq homology of immunogen across species: Mouse (91%), Chicken (85%), Rat (84%), Xenopus laevis (86%), Bovine (92%)
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Glycine, serine and threonine metabolism, Metabolic pathways

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