KLRA1 (KLRA1P) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 - 2 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	KLRA1 antibody was raised against a 13 amino acid peptide near the carboxy terminus of human KLRA1.
Isotype	IgG
Formulation	PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	Affinity chromatography purified via peptide column
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	killer cell lectin like receptor A1, pseudogene
Database Link	NP_006602 Entrez Gene 10748 Human
Background	KLRA1 (also known and Ly49L) is a member of the LY49 family of receptors Natural killer (NK) cells that bind to major histocompatibility complex (MHC) class 1. These proteins are classified as either activating or inhibitory receptors based on whether they possess an immunoreceptor tyrosine-based inhibitory motif (ITIM) in their cytoplasmic region (for inhibitory receptors), or an immunoreceptor tyrosine-based activation motif (ITAM) that transmits activating signals resulting in phosphorylation of several substrates. KLRA1 is thought to be an activating receptor, inducing DAP12 phosphorylation in response to antibody-mediated cross-linking of KLRA1 on NK cells. At least three isoforms of KLRA1 are known to exist.
Synonyms	A1; class I MHC receptor KLRA22; killer cell lectin-like receptor; KLRA#; Klra22; Ly-49L; Ly49; Ly49a; LY49L; Ly49o; Ly49v; member 1; MGC126520; MGC126522; natural killer cell receptor Ly49A; OTTMUSP00000026268; subfamily A
Reference Data
Protein Families	Transmembrane

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