TSLP Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IF, IHC, WB
Recommend Dilution	WB: 0.25 - 4 µg/mL IHC-P: 1-2.5 µg/mL. Antibody validated: Western Blot in human and mouse samples Immunohistochemistry in human and mouse samples. All other applications and species not yet tested.
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Anti-TSLP antibody (4023) was raised against a peptide corresponding to 19 amino acids near the center of human TSLP. The immunogen is located within the amino acids 40-90 of TSLP.
Isotype	IgG
Formulation	TSLP Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/mL
Purification	TSLP Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	TSLP antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures.
Predicted Protein Size	Predicted: 18 kD Observed: 17, 24 kD (Post-modifications: 2 N linked glycosylations)
Gene Name	thymic stromal lymphopoietin
Database Link	NP_149024 Entrez Gene 53603 MouseEntrez Gene 85480 Human UniProt ID Q969D9
Background	TSLP Antibody: Thymic stromal lymphopoietin (TSLP) has recently been identified as an important factor capable of driving dendritic cell maturation and activation. TSLP is a four-helix-bundle cytokine that is expressed mainly by barrier epithelial cells and is a potent activator of several cell types such as myeloid dendritic cells. TSLP is involved in the positive selection of regulatory T cells, maintenance of peripheral CD4+ T cell homeostasis and the induction of CD4+ T cell-mediated allergic reaction. TSLP is also capable of supporting the growth of fetal liver and adult B cell progenitors and their differentiation to the IgM-positive stage of B cell development. Amino acid sequence analysis has shown poor homology between human and mouse TSLP although they exhibit similar biological functions and are expressed in similar tissues. At least two differentially spliced isoforms of TSLP are known to exist.
Synonyms	thymic stromal lymphopoietin
Note	Optimal dilutions for each application to be determined by the researcher.
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway

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