Hamartin (TSC1) Rabbit Polyclonal Antibody

CAT#: TA306217

Rabbit Polyclonal TSC1 Antibody



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CNY 5,808.00


货期*
5周

规格
    • 100 ug

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Transient overexpression lysate of tuberous sclerosis 1 (TSC1), transcript variant 1
    • 100 ug

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Specifications

Product Data
Applications WB
Recommend Dilution WB: 2 - 4 ug/mL
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Immunogen Rabbit TSC1 (CT) polyclonal antibody was raised against a 15 amino acid peptide from the carboxy terminus of human TSC1.
Formulation PBS containing 0.02% sodium azide.
Concentration 1ug/ul
Purification Affinity chromatography purified via peptide column
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name tuberous sclerosis 1
Background Tuberous sclerosis complex (TSC) is an autosomal dominant tumor syndrome caused by mutations in either of the TSC1 or TSC2 tumor suppressor genes. The products of these genes form a protein complex that indirectly decreases the signaling of the mammalian Target of Rapamycin (TOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors (reviewed in 1,2). TOR activity is stimulated by Rheb, a member of the Ras superfamily of G-proteins, when the GTP/GDP ratio bound to Rheb is high (3). Immunoprecipitated TSC1/TSC2 has been shown to stimulate Rheb GTPase activity in vitro (4), suggesting that the TSC1/TSC2 decreases the ability of Rheb to stimulate TOR activity. This is supported by experiments showing overexpression of TSC1 and TSC2 results in a significant decrease in the GTP/GDP ratio bound to Rheb and the inhibition of cell growth (4,5). A shorter 40 kDa isoform of TSC1 has been shown to exist but its function is unknown.
Synonyms LAM; TSC
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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