MD2 (LY96) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 0.5 - 2 ug/mL, ICC: 2 ug/mL, IF: 10 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	MD-2 antibody was raised against a peptide corresponding to 13 amino acids near the center of human MD-2. The immunogen is located within the last 50 amino acids of MD-2.
Formulation	PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	Ion exchange chromatography purified
Conjugation	Unconjugated
Storage Condition	Antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures.
Gene Name	lymphocyte antigen 96
Database Link	NP_056179 Entrez Gene 17087 MouseEntrez Gene 448830 RatEntrez Gene 23643 Human UniProt ID Q9Y6Y9
Background	MD-2 is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs) (1-3). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses (4). TLR4, the major signaling receptor for lipopolysaccharide (LPS), requires the binding of MD-2 to its extracellular region for maximal response to LPS (5,6). The specificity of this response is determined by the species of MD-2; e.g., human MD-2 can cause mouse TLR4 to react to LPS analogs that are normally antagonistic to human but not mouse TLR4 (7).
Synonyms	ESOP-1; ly-96; MD-2; MD2
Reference Data
Protein Families	Secreted Protein
Protein Pathways	Pathogenic Escherichia coli infection, Toll-like receptor signaling pathway

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