TLR10 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IF, WB
Recommend Dilution	TLR10 antibody can be used for detection of TLR10 by Western blot at 0.5 to 1 µg/mL. Despite its predicted size of ~90 kDa, a band correpsonding to TLR10 is observed at ~75 kDa in immunoblot assays. For immunofluorescence start at 2 µg/mL. Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	TLR10 antibody was raised against a peptide corresponding to 14 amino acids near the middle of human TLR10.
Isotype	IgG
Formulation	PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	TLR10 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	toll like receptor 10
Database Link	AAQ88667 Entrez Gene 81793 Human UniProt ID Q9BXR5
Background	Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1-3). These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors (4,5). TLR10 is highly homologous to TLRs 1 and 6 and is most highly expressed in lymphoid tissues (6). Most recently genetic variation in TLR10 has been associated with contributing to asthma risk (7). It should be noted that TLR10 exists in mice only as a pseudogene (8).
Synonyms	CD290
Reference Data

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