KLHL1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 2 - 4 ug/mL, ICC: 10 ug/mL
Reactivity	Human, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	KLHL1 antibody was raised against a 14 amino acid peptide from near the amino-terminus of human KLHL1.
Isotype	IgG
Formulation	PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	immunoaffinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	kelch like family member 1
Database Link	AAF81719 Entrez Gene 57626 Human UniProt ID Q9NR64
Background	The mammalian Kelch-like 1 (KLHL1) was initially discovered as a homolog to the Drosophila Kelch gene that is highly expressed in several brain tissues (1,2). The predicted protein domain structure of KLHL1 is characteristic of a number of proteins that bind actin, form dimers, and often act as actin-organizing proteins (3). Based on the presence of anti-sense RNA that spans the transcription and translation start sites as well as the first splice site of KLHL1 in brain tissue of individuals suffering from the neurodegenerative disorder spinocerebellar ataxia type 8 (SCA8), it has been suggested that KLHL1 is involved this disease and that regulation of KLHL1 protein may be affected by antisense RNA expression (1).
Synonyms	MRP2
Reference Data

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