BNIP3L Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 ug/mL, ICC: 2 ug/mL, IF: 10 ug/mL
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Bnip3L antibody was raised against a peptide corresponding to amino acids 77 to 92 of human origin, which are identical to those of mouse Bnip3L.
Isotype	IgG
Formulation	PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	Affinity chromatography purified via peptide column
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	BCL2/adenovirus E1B 19kDa interacting protein 3-like
Database Link	NP_004322 Entrez Gene 665 Human UniProt ID O60238
Background	Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, Hrk, Nip3, and Bim, form a growing subclass of the Bcl-2 family. A novel BH3 domain containing protein was recently identified and designated Bnip3L, Bnip3alpha, and Nix (for Nip3-like protein X) (1-3). Bnip3L/Bnip3alpha/Nix is a homolog of the E1B 19K/Bcl-2 binding and pro-apoptotic protein Bnip3. Overexpression of Bnip3L induces apoptosis (2,3). Bnip3L interacts with and overcomes suppresses by Bcl-2 and Bcl-xL. Bnip3L is localized in mitochondria. The messenger RNA of Bnip3L is ubiquitously expressed in human tissues (1,2). Bnip3L and Bnip3 form a new subfamily of the pro-apoptotic mitochondrial proteins.
Synonyms	BNIP3a; NIX
Reference Data
Protein Families	Druggable Genome, Transmembrane

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