ALS2 Goat Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 3-5ug/ml.
Reactivity	Human, Mouse, Rat, Dog, Cow
Host	Goat
Clonality	Polyclonal
Immunogen	Peptide with sequence LKACYYQIQREKLN, from the C Terminus of the protein sequence according to NP_065970.2.
Isotype	IgG
Formulation	0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
Concentration	lot specific
Purification	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20C. Minimize freezing and thawing.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	ALS2, alsin Rho guanine nucleotide exchange factor
Database Link	NP_065970 Entrez Gene 74018 MouseEntrez Gene 363235 RatEntrez Gene 100856109 DogEntrez Gene 57679 Human UniProt ID Q96Q42
Background	The protein encoded by this gene contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in this gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Synonyms	ALS2CR6; ALSJ; IAHSP; PLSJ
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Amyotrophic lateral sclerosis (ALS)

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